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Methyl Factors provides vitamins B6, B12, and folate in a unique liquid form to support the reduction of homocysteine levels for heart health.†

Item # Product Size
612 Methyl Factors 2 oz.

Essential for proper neurological function.†
Nutritional support for normal erythropoiesis.†
Supplies vitamin B6, B12, and folate.†

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Folic acid and homocysteine

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Product Details†


- Supports optimal homocysteine levels for cardiovascular health†
- Helps maintain proper neurological function†
- Nutritional support for normal erythropoiesis†

METHYL FACTORS provides therapeutic doses of vitamins B6, B12, and folate in a highly absorbable liquid formula. These essential B vitamins support proper endogenous methylation activity as well as healthy production of red blood cells, neurotransmitters, hormones, and nucleic acids. The compound homocysteine occurs as a byproduct of the series of B12/B6/folate-dependent methylation reactions involved in methionine/cysteine metabolism. Elevated levels of homocysteine have been associated with cardiovascular risk through believed promotion of atherosclerotic plaque development and enhanced blood clotting activity. In clinical trials, supplementation with the involved B vitamins has been shown to reduce circulating homocysteine levels and therefore support cardiovascular health.†

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FOLATE (FOLIC ACID) is provided as a combination of 5-methyltetrahydrofolate (5-MeTHF) and 5-formyltetrahydrofolate (calcium folinate). Although, folic acid is the most oxidized and stable form of folate and is commonly used as a dietary supplement, it is not the metabolically active form. Folic acid must be reduced and methylated to 5-MeTHF to become the metabolically active form found in blood and utilized by tissues. Research has shown a subset of individuals with MTHFR polymorphism do not efficiently convert folic acid to the active 5-MeTHF due to genetic enzyme deficiencies. It is important to remember that 5-MeTHF is A form of the methyl group donor required for the conversion of homocysteine to methionine, which is catalyzed by vitamin B12-dependent methionine synthase. Without sufficient 5-MeTHF, regeneration of methionine cannot occur, resulting in possible homocystenemia.†

VITAMIN B6 (PYRIDOXAL 5’-PHOSPHATE) is a water-soluble vitamin that participates in over 100 body reactions. The phosphate ester derivative pyridoxal 5’-phosphate (PLP) is the principle coenzyme form and is a cofactor for endogenous transaminase activity. PLP-dependent reactions include the synthesis of both serotonin and the catecholamines and the production of hemoglobin, steroid hormones, and nucleic acids. Vitamin B6 deficiency has been linked to emotional abnormalities, carpal tunnel, low immunity, and premenstrual syndrome. Conversion of homocysteine to the amino acid cysteine requires two PLP-dependent reactions. This pathway facilitates the de novo synthesis of cysteine from methionine and also provides an alternative pathway for the breakdown of homocysteine.†... Click here to continue reading

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For Questions or Orders Call (866) 272-0500

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.