and longevity medicine. Physiological and cellular stress has been shown to increase telomere shortening and may explain why those under stress frequently age faster than those who are not. There are several nutrients that can help preserve telomere length and decrease cellular aging.†

RESVERATROL is a potent antioxidant found in red wine and has been shown to increase the life span and physical endurance in mammals. Resveratrol may enhance health and longevity via several mechanisms. One mechanism is by promoting the activation of sirtuins, a class of histone deacetylase enzymes (HDACs) involved in cell death and life-span regulation. Resveratrol has also been shown to regulate telomerase activity, thus protecting telomeres from damage. Until the more recent discovery of resveratrol’s life extending benefits, practicing a calorie restriction diet while maintaining good nutritional status was the only scientifically supported practice for extending the life span. The genetic pathways influenced by resveratrol are similar to those affected by a calorie restricted diet. For example, they both are associated with the long term activation of AMP-activated kinase (AMPK). Increased AMPK activity appears to lengthen lifespan by promoting insulin sensitivity.†

ASTRAGALUS is considered to be one of the most promising telomere anti-aging compounds after Resveratrol and Oligomeric Proanthocyanidins. Some studies indicate that this extract may have telomere protective properties. Astragalus is also known to support the immune system. Astragalus contains Astragolsides that have shown promise. The rare Astragoloside IV molecule, otherwise known as TA-65 may have telomere lengthening properties thus promoting enhanced cellular health, cellular regenerative functions and cellular longevity.†

PINE BARK EXTRACT AND GRAPE SEED EXTRACT contain oligomeric proanthocyanadins (OPCs), a group of bioflavonoids. Pine bark extract contains several active constituents including flavonoid monomers such as catechin, epicatechin, and
taxifolin. It also contains condensed procyanidins (also called flavonoids or proanthocyanidins). Both extracts have documented effectiveness as free radical scavengers. There is evidence that OPC’s may play a role in inhibiting proteolytic enzymes that are involved in the degradation of skin and vasculature.†

GREEN TEA EXTRACT: Polyphenols, the active constituents of green tea, include catechins ... Click here to continue reading